Glycodelin and differentiation in endometrium and ovary: Clinical aspects related to reproduction and epithelial ovarian cancer
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چکیده
...................................................................................................... 7 REVIEW OF THE LITERATURE
منابع مشابه
The Roles of Glycodelin in Cancer Development and Progression
Glycodelin is a kind of glycoprotein expressed in secretory endometrium, pregnancy deciduas, and amniotic fluid originally, which is vital for the maintenance of normal human reproductive activities. Recent researches have reported that glycodelin is specifically expressed in various malignancies, including female-specific cancers such as endometrial cancer, ovarian cancer and breast cancer, an...
متن کاملDevelopment of monoclonal and polyclonal antibodies and an ELISA for the determination of glycodelin in human serum, amniotic fluid and cystic fluid of benign and malignant ovarian tumors.
OBJECTIVE The role of glycodelin in human reproduction and gynecological malignancies has been investigated in a large number of studies in recent years. Three dominant functions of this glycoprotein were identified. Glycodelin is immunosuppressive, a morphological marker of differentiation and a contraceptive. Glycodelin is a glycoprotein with a molecular weight of 28 kDa and a carbohydrate co...
متن کاملClinical Utility of Serum Glycodelin as a Novel Marker for Ovarian Cancer
Ovarian cancer is a cancerous growth arising from different parts of the ovary. It has been called "Silent killer" because it frequently causes non-specific symptoms. CA125 was the first tumor marker available for detection of ovarian cancer but the major problem is its poor sensitivity and specificity as it is elevated in only 40-50 % of patients with stages І and ІІ ovarian cancer. Glycodelin...
متن کاملGlycodelin: a major lipocalin protein of the reproductive axis with diverse actions in cell recognition and differentiation.
Glycodelin is a glycoprotein that belongs to the lipocalin superfamily. Depending on glycosylation, glycodelin appears in various isoforms. In the uterus, glycodelin-A is the major progesterone-regulated glycoprotein secreted into uterine luminal cavity by secretory/decidualized endometrial glands. The other tissues expressing glycodelin include fallopian tubes, ovary, breast, seminal vesicle, ...
متن کاملCase report: A Metastatic Transitional Cell Carcinoma of the Ovary
Background: Transitional cell carcinoma (TCC) is a rare type of ovarian epithelial cancer. This type of ovarian cancer accounts for only 1% of superficial epithelial carcinomas. Ovarian cancer is a major clinical challenge in obstetrics and gynecology. The reason of this is the lack of specific symptoms for ovarian cancer before the recurrence and progression of the tumor, so many cases are not...
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تاریخ انتشار 2003